Other Forms of Antagonism

Allosteric antagonism. The antagonist is bound outside the agonist s site of attachment at the receptor and induces a decrease in agonist af nity. The latter is increased in the case of allosteric synergism. 

Functional antagonism. Two agonists acting via different receptors affect the same variable (e.g., luminal diameter of bronchi) in opposite directions (epinephrine — dilation histamine — constriction). 

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Agonist induces active conformation of receptor protein 

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Other forms of antagonism In addition to pharmacologic antagonism, there are two other mechanisms by which a drug can inhibit or block the effects of an agonist ... 

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