Other Enantioselective Chromatographic Techniques

When a racemic mixture is introduced into a chromatographic system containing cyclodextrin, the two isomers will have a different affinity for the chiral phase, affording what is called the enantioselectivity of the cyclodextrin phase. Finally, one other approach to the separation of enantiomers that has been applied in forensic work is enantioselective derivation. Rather than using an optically active stationary phase, this technique achieves separation by derivatizing the chiral compounds with chiral agents resulting in different selectivities for chiral molecules. 

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