Orthogonal chemistry, controlled

By far the most popular technique is based on simplex methods. Since its development around 1940 by DANTZIG [1951] the simplex method has been widely used and continually modified. BOX and WILSON [1951] introduced the method in experimental optimization. Currently the modified simplex method by NELDER and MEAD [1965], based on the simplex method of SPENDLEY et al. [1962], is recognized as a standard technique. In analytical chemistry other modifications are known, e.g. the super modified simplex [ROUTH et al., 1977], the controlled weighted centroid , the orthogonal jump weighted centroid [RYAN et al., 1980], and the modified super modified simplex [VAN DERWIEL et al., 1983]. CAVE [1986] dealt with boundary conditions which may, in practice, limit optimization procedures. 

Blanc, A. and Bochet, C.G. (2002) Wavelength-controlled orthogonal photolysis of protecting groups. Journal of Organic Chemistry, 67, 5567—5577. 

From Kharkar, P.M., Kiick, K.L., Kloxin, A.M., 2013. Designing degradable hydrogels for orthogonal control of ceU microenvironments. Chem. Soc. Rev. 42 (17), 7335—7372, published by The Royal Society of Chemistry. 

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