Ormosils formulations

For this reason, corrosion inhibitors such as cerium salts or organic biocides are successfully added to the silane sol-gel layer. Akid and coworkers, for example, have developed a broad range of chromate-free xerogel coatings based on doped Ormosil formulations with very high corrosion resistance and with little evidence of change after extensive salt spray tests for a variety of different metal substrates (aluminum alloys, steel, magnesium, etc.). 

An example of the appropriate application of organically-modified silica precursors is alkoxides with an alkyl group. When methyltrimethoxy- or methyl-triethoxysilane (Figure 3.2) was added in formulations to increase the hydro-phobicity of ORMOSILs, it resulted in a better enzymatic activity of lipases immobilized in the alkyl-modified silica than in a hydrophilic matrix fabricated by means ofTEOS alone [51,80,129-133]. Similarly, an increased stability of lipase from Candida antarctica B was observed after its immobilization in a silica matrix... 

The formulation of the ORMOSIL precursor is chosen in the light of screening experiments (Figure 6.13). For the recognition of ovalbumin, for example, the precursor is a 55 mol% TEOS, 2 mol% 3-aminopro-pyltriethoxysilane (APTES), 3 mol% n-octyItrimethoxysi 1 ane (C8-TMOS) and 40 mol% bis(2-hydroxyethyl)aminopropyltriethoxysilane (HAPTS) mixture. The resulting microarray sensor exhibits analytical... 

These studies provide the groundwork for the use of ORMOSIL nanoparticle formulations for in vivo gene transfer into the central nervous system, and demonstrate that ORMOSIL nanoparticles can potentially provide a safe and efficient mechanism for in vivo gene therapy. The results of this nanomedicine approach... 

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