Organs tobramycin

The answer is a. (Hardman, pp 1105-1108.) The activity of streptomycin is bactericidal for the tubercle bacillus organism. Other aminoglycosides (e.g., gentamicin, tobramycin, neomycin, amikacin, and kanamycin) have activity against this organism but are seldom used clinically because of toxicity or development of resistance. 

Streptomycin binds with specific proteins (S12) on 30 S subunits of ribosomes. A change in this protein as a result of a mutation makes the ribosomes unable to bind with streptomycin, which makes the organism resistant. Mutational resistance to streptomycin occurs frequently. Gentamicin, tobramycin, netilmicin, and amikacin bind with many regions on both subunits of the ribosomes, and therefore mutational resistance to them is not common. 

P. aeruginosa is commonly found in the bronchial secretions of patients with cystic fibrosis. In one study, daily inhalation of large doses of tobramycin decreased the colonization by this organism 100-fold and significantly improved pulmonary function. 

Generally, streptomycin and gentamicin are used to treat infections with gram-positive organisms, whereas gentamicin, tobramycin, and amikacin are used to treat infections with gram-negatives. 

Tobramydtt. The antibacterial activity and pharmacokinetic properties of tobramycin resemble those of gentamicin, and the therapeutic uses of tobramycin are essentially identical to those for gentamicin. Although some bacteria are resistant to both gentamicin and tobramycin, it is impredictable in individual strains. Amikacin is usually effective for infections caused by organisms resistant to both gentamicin and tobramycin. 

Initial treatment of bacterial ophthalmia neonatorum should be directed by the results of conjimctival smears. Broad-spectrum antibiotics with low toxicity should be used. Topical erythromycin or tetracycline ointment can be used four to six times daily fc>r gram-positive organisms, and gentamicin or tobramycin solution four to six times daily can be started if gram-negative organisms are isolated. Trimethoprim-polymyxin B (Polytrim) has... 

Tobramycetin tobramycin, tobramycin [ban, inn, jan, usan] (nebramycin VI Tobramycetin etc.) is an (aminoglycoside) ANTIBIOTIC. Clinically, it has ANTIBACTERIAL properties, and is mainly used against Gram-negative organisms by systemic administration (it is not absorbed orally). tobuterol terbutaline. 

The remarkably successful clinical application of aminoglycoside antibiotics attracted the attention of many organic chemists. With his continuous interest in this field for more than 20 years, Sumio Umezawa accomplished the first total synthesis of many aminoglycosides, including paromamine,- neamine," trehalosamine, kanamycins A, B, and C, 2 butirosin B, tobramycin, " streptomycin, dihydrostreptomycin, and neomycins B and C. ... 

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