Organometallic reagents conjugate addition

House investigated the role of cuprous ions in the conjugate addition of organometallic reagents. He found that the catalytic effect can be explained by the intervention of a methyl copper derivative, which reacts rapidly with the carbon-carbon double bonds of the conjugated system. 

I.5.2.I.I.4. Conjugate Addition of Chiral Organometallic Reagents External Stoichiometric Chiral Ligands... 

TABLE 6. Conjugate addition of organometallic reagents to vinyl sulfones55... 

Deprotonation of the vinylic proton is a serious side-reaction in the conjugate addition of organometallic reagents to y-siloxy-a, /J-unsaturated sulfones (89)63b. The use of the... 

Tomioka K, Nagaoka Y (1999) Conjugate addition of organometallic reagents. In Jacobsen EN, Pfaltz A, Yamamoto H (eds) Comprehensive asymmetric catalysis, vol 3. Springer, Berlin Heidelberg New York, chap 31.1... 

Another very important method for specific enolate generation is the conjugate addition of organometallic reagents to enones. This reaction, which not only generates a specific enolate, but also adds a carbon substituent, is discussed in Section 8.1.2.3. 

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