Organomagnesium amides synthesis

This chapter is devoted to the chemistry of organomagnesium-group 15- and group 16-bonded complexes, with emphasis on their synthesis, structural characterization and utility. In particular, organomagnesium amides will be the central focus of the first section, as... 

Detailed reviews on the structures of organomagnesium compounds and the constitution of their solutions have been published [D, 1, 2]. These references, especially the first two, also cover alkylmagnesium hydrides, amides, alkoxides and thiolates. However, while all of these compounds are of intrinsic interest, they are little used in synthesis. 

The synthesis of ketones from organomagnesium compounds and N,N-dialkylamides has been comparatively little exploited, but a few examples are included in Table 6.5. A significant limitation has been the low reactivity of the amides, but this has been overcome by the use of 7V-(2-pyridyl)amides (see penultimate entry in Table 6.5) and especially A-methoxyamides (hydroxamates). Examples of the use of the latter are listed in Table 6.6. 

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