Amides pyridyl

Besides the ester and imide derivatives that are known to be polymerized by the noble metal catalysts, nitrile, amide, pyridyl and acid anhydride derivatives were found to undergo polymerization by the present catalyst systems. The ester derivatives were easily polymerized by the binary catalyst to a high conversion at the catalyst-to-monomer molar ratio as low as 10. The nitrile derivatives were less reactive but... 

Initialiy, 4-bromobenzyl-cyanide is reacted with sodium amide and 2-chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyi amino ethyl chloride to give 4.bromophenyl-dimethylamlnoethyl-pyrldyi acetonitrlie. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maieate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanoi. 

According to U.S. Patent 2,676,964 to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of 3reaction product decomposed with water and ether extracted. The ether layer is dried over Sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid. 

N-tert-butyl-2-(5-benzyloxy-6-hydroxymethyl-2-pyridyl )-2-hydroxyacet amide... 

Aminomethyl-pyridin hzw. Pyridin-2-carbonsaure-[pyridyl-(2)-metbylimid]-amid ... 

In accordance with the electropositive nature of the bridgehead atoms, all di(pyridyl) substituted anions behave like amides with the electron density accumulated at the ring nitrogen atoms rather than carbanions, phosphides or arsenides. The divalent bridging atoms (N, P, As) in the related complexes should in principle be able to coordinate either one or even two further Lewis acidic metals to form heterobimetallic derivatives. According to the mesomeric structures, (Scheme 7), it can act as a 2e- or even a 4e-donor. However, theoretical calculations, supported by experiments, have shown that while in the amides (E = N) the amido nitrogen does function as... 

Fig. 7. The solid state structures of the di(pyridyl)methanide [53], -amide [52], -phos-phide[27] 13 and -arsenide [43] all containing the Me2Al cationic fragment. Although the Al-N distance is almost invariant in all structures the more acute C-E-C angle (As < P < N < CH) forces the complex in a more pronounced butterfly arrangement...

Linear multinuclear metal complexes are attracting attention in the context of molecular electronics due to their projected use as molecular wires. 01igo(pyridyl)amido ligands are efficient scaffolds for lining up several Ni11 ions like a string. The first structurally characterized trinickel complex of this type, [Ni3(dpa)4Cl2] (dpa = bis(2-pyridyl)amide), showed a nearly linear Ni3 unit with Ni—Ni distances of around 244 pm.209 Penta-, hepta-, and nonanuclear systems have... 

With N,0 mixed donor ligands several complexes have been reported with ligands such as 4,5-dichloro-2-cyano-3,6-dione-l,4-cyclohexen-l-ol,1445 isonicotinic acid,1446 p-aminobenzoic acid,1447 alanine, histidine or histamine derivatives,1448-1450 [N(0)C(CN)2]-,1451 pyridine-carboxylate derivatives, 1452 1454 [N(pph20)2] (263),1455 bis(sulfonyl)amide derivatives,1456,1457 tris(pyridyl)-... 

The zinc complexes with diphenyl-2-pyridylmethane, ZnL2Cl2 and ZnL2Br2, have been characterized by IR spectroscopy and conductivity measurements.107 The [(pyridyl)2P(NSi Mc3)2] ligand forms an aminoiminophosphoranate complex with zinc which structural characterization shows to be four-coordinate bound to two pyridyl and two amide nitrogen donors (3).108... 

Treatment of 3-(4-rncthylphcnylarnino)-4-(4-methylphcnylirnino)A//-pyndo[ 1,2- ]pyrazinc 319 (Ar = 4-MeC6H4) with 30% H202 in acetone at 50 °C and with sodium bis(trimethylsilyl)amide and (norbornadiene)Mo(Co)4 in THF gave l-(4-methylphenyl)-2-(2-pyridyl)-4-(4-methylphenylamino)-l, 2-dihydro-57/-imidazol-5-one complex 318 <1995JPR38>. 

Figure 5.2 SPDP can react with amine-containing molecules through its NHS ester end to form amide bonds. The pyridyl disulfide group then can be coupled to a sulfhydryl-containing molecule to create a cleavable disulfide bond.

A pyridyl bis-N-heterocydic carbene (NHC) ligand has been prepared by Steel and Teasdale based on nudeophilic aromatic substitution of dichloroisonicotinic amides with N-methylimidazole (Scheme 6.122) [250]. Microwave heating of the neat reagents at 140 °C for 10 min provided a 91% yield of the corresponding bis-... 

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