Organocopper reagents palladium catalysis

The more reactive lithium dialkenylcuprates (R2CuLi) cannot be directly acylated even at low temperature, because further addition to the product takes place. These reagents can be modified in situ so that the actual species undergoing reaction is an organozinc (requires palladium catalysis) however, other methods for generating organozincs are available that do not involve prior organocopper formation (Section 1.13.4.4). Stoichiometric vinylcopper and other copper-mediated acylations were not directly applicable to the case shown in equation (58) (however, see Section 1.13.2.1). 

An Organometallic Com pound That Occurs Naturally Coenzyme B,2 591 Organocopper Reagents 592 Palladium-Catalyzed Cross-Coupling 595 Homogeneous Catalytic Hydrogenation 597 Olefin Metathesis 600 Ziegler-Natta Catalysis of Alkene Polymerization 603 Summary 606 Problems 608... 

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