Organocatalytic Asymmetric Reductive Amination

Scheme 14. Organocatalytic asymmetric reductive amination of ketones...

Aspects featured in a review of asymmetric reductive aminations have included transition metal-mediated homogeneous-, enantioselective organocatalytic-. 

As detailed in Sections 42.2 and 42.3, both covalent and non-covalent organocatalytic activation modes have provided efficient strategies to design asymmetric MCRs. A quite recent study by Zhou and list has demonstrated the feasibility of combining asymmetric Bronsted acid catalysis with aminocatalysis to design even more sophisticated reaction sequences toward the synthesis of useful complex molecules. Specifically, they developed a highly enantioselective approach to pharmaceutically relevant 3-substituted cyclohexylamines from 2,6-diketones 223 via an aldolization/dehydration/conjugate reduction/reductive amination domino... 

Enders D, Liebich JX, Raabe G. Organocatalytic asymmetric s3mthesis of tra j-l,3-disubstituted tetrahydroisoquinolines via a reductive amination/aza-Michael sequence. Chem. Eur. J. 2010 16(32) 9763 9766. 

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