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Reductive amination antibody conjugation

Figure 7.11 Oxidation of glycoproteins with periodate, such as glycosylated antibodies, results in the formation of aldehyde groups that can be used for conjugation to dendrimers containing amine groups. Reductive amination with sodium cyanoborohydride results in coupling via secondary (or tertiary) amine bonds. Figure 7.11 Oxidation of glycoproteins with periodate, such as glycosylated antibodies, results in the formation of aldehyde groups that can be used for conjugation to dendrimers containing amine groups. Reductive amination with sodium cyanoborohydride results in coupling via secondary (or tertiary) amine bonds.
A second method of immunotoxin preparation by reductive amination involves the use a polysaccharide spacer. Soluble dextran may be oxidized with periodate to form a multifunctional crosslinking polymer. Reaction with antibodies and cytotoxic molecules in the presence of a reducing agent forms multivalent immunotoxin conjugates. The following sections discuss these options. [Pg.855]

Conjugation of Periodate-Oxidized HRP to Antibodies by Reductive Amination... [Pg.475]

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See also in sourсe #XX -- [ Pg.803 ]

See also in sourсe #XX -- [ Pg.475 ]

See also in sourсe #XX -- [ Pg.475 ]



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Amine conjugating

Antibodies conjugation

Antibodies reduction

Antibody conjugates

Conjugate reduction

Conjugation amine

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