Carbene-Based Dual Organocatalysis

In 2007, Cordova and coworker [17] first found that amino and heterocyclic carbene catalysis could be combined in one-pot for the direct catalytic conversion of a,P-unsaturated aldehydes into valuable P-functionalized esters in good to high yields with excellent enantioselectivities (Scheme 43.8). The one-pot combination of chiral amine and heterocyclic carbene catalysis opens up the possibility of bio-mimetic asymmetric dual organocatalysis based on carbene catalysis. 

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