Organic synthesis background

L. KUrti, B. Czak6, Strategic applications of named reactions in organic synthesis. Background and detailed mechanisms. Elsevier Academic Press, Amsterdam, The Netherlands, 2005. 

In view of this background, it is the aim of this chapter to organize the fundamentals of radical additions to 1,2-dienes and to present its state of the art in organic synthesis. All aspects of enyne allene cyclizations [19, 20] have been omitted since this topic is addressed in Chapter 20. In order to simplify the mechanistic discussion, the positions and Jt-bonds of allenes have been consistently numbered using the nomenclature outlined in Figure 11.1. 

The numerous substitution reactions lay in the background of the application of metal alkoxides in inorganic and metal-organic synthesis (preparation of halides, hydrides, sulfides, carboxylates, alkyl derivatives, certain classes of coordination compounds, etc.). One advantage of their application is the formation of only alcohols as by-products ... 

Not much could be added to the above quotations with regard to the role of both imagination and knowledge as complementary components of the true creativity in organic synthesis (or, for that matter, in any other area of both science and art). In the context of this chapter, however, it is essential to take a closer look at the rational background of modern organic synthesis, and its logistics as especially important components of the problem solutions in this area. 

Compound II was required in moderate quantity and chlorohydrin (I) was available in the laboratory from a previous project. Anyone with a standard background of organic synthesis would readily select lithium aluminum hydride (LAH) as the reagent of choice for the apparently simple reduction of the secondary halide. The reaction was in fact run but something funny happened on the way to compound II. Three other major products appeared, let alone the fact that II was obtained only in 5% yield. 

With a brief historical background and general principles of free radical chemistry applicable to organic and aqueous media, we shall next turn our attention to the study of radical chemistry in aqueous media as its applies to organic synthesis and use the concepts that will emerge as the foundation upon which the rest of the material will rely and build upon. 

Volume 78, issue 1 (2006), was dedicated to the theme of the application of organometallic chemistry to organic synthesis. Individual articles in this issue provide useful historical background. 

A few medicinal chemists in industry do their own modeling work. Some enjoy it, are proficient enough, and are willing to dedicate the time it takes. They might do this by choice or because they work for companies too small to have hired modelers yet. Most, however, do work with modelers. These valuable team members often have a background in organic synthesis so that they can tell which proposed structures are synthetically tractable and which aren t. 

Diels-Alder Methodology in Organic Synthesis, Academic Press, San Diego, 1987. (d) Taber, D. R, Intramolecular Diels-Alder and Alder Ene Reactions, Springer-Verlag, Berlin, 1984. (e) Hamer, J., 1,4-Cycloaddition Reactions, the Diels-Alder Reaction in Heterocyclic Syntheses, Academic Press, New York, 1967. (f) Wassermann, A., Diels-Alder Reactions Organic Background and Physicochemical Aspects, Elsevier Publications, Amsterdam, 1965. 

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