Organic Azides and Azido Derivatives

Organic Amides and Imides A170 Al7l Organic Azides and Azido Derivatives A626 to A643... 

An unprecedented example of the application of an organic azide as an enzyme inhibitor derives from the elegant studies of Stubbe and coworkers at MIT, who have investigated the mechanism of action of ribonucleotide reductase (RNR) using several mechanism-based inhibitors including 2 -azido-2 -deoxyuridine-5 -diphosphate (NjUDP) (71) [82]. RNR plays a... 

Several carbohydrate applications have been included in a review of micro-wave-assisted organic reactions, and a survey of chemical reagents in photo-aflinity labelling included the role of various base-labelled azido- and thio-nucleosides, sugar azide derivatives and p-benzoylbenzoate esters of nucleosides. A further review intitled Reverse Anomeric Effect Fact or Fiction refers to early evidence based on studies of glycosyl pyridinium and imidazolium salts. It concludes that its origin as an electronic effect is not supported by theory or experimental results. ... 

This change in editorial leadership has resulted, perhaps inevitably, in a change in editorial policy which is reflected in the contents of Volume 8. There has been a marked de-emphasis on the inclusion of organic parent compounds followed by an exhaustive and voluminous cataloging of azide, azido, azo, diazido, diazonium, diazo, nitro, dinitro, polynitro, hitr amine, nitrate (esters and salts), dinitrate, poly nitrate, nitroso, polynitroso, chlorate, perchlorate, peroxide, picrate, etc, derivatives — regardless of whether any of these derivatives exhibit documented explosive or energetic properties. Only those materials having such properties have been included in this volume... 

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