Ordered mechanism three-substrate reactions, initial rate

An enzyme reaction scheme in which there are two substrates (A and B) and three products (P, Q, and R) and in which the substrates bind and the products are released in an ordered fashion. This reaction scheme is exemphfied by the malic enzyme The initial rate expression, in the absence of abortive complexes and products, is identical to the corresponding equation for the ordered Bi Bi mechanism. See Multisubstrate Mechanisms Ordered Bi Bi Mechanism... 

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