ORD characteristics

Modelling and Strangening Nucleic Acids by Polynucleotide Strand-Analogues 

Base and sugar variants of nucleosides and nucleotides have been dealt with in the past in an abundance, nearly incapable for reviews, monographs or even reference journals (26,121-123). While these variants of a first and second generation of analogues still continue attracting the attention of people interested in nucleic acid chemistry and its applica- 

To deal only with those structures, modelled from a greater distance, there opened for synthetical approaches ways of polycondensation, polyaddition free-radical, photochemical, or -ray induced polymerizations or polymeranalogous reactions, possibilities that have been met in the meantime by numerous synthetic efforts, reviewed already by different authors (26,59,97,128-130,132,133). 

As a compromise between the screening postulations of rapid and uncomplicated access to high molecular systems (due to the selections of a size criterion for interaction possibilities of biopolymers within bioregulation hierarchies (134)) by a route independent from the natural polycondensation way (due to a greater suitability for the alternatives of matrix polymerizations) and a certain degree of stereo-electronic order of our synthetics (due to the desire for reproducibility and fit of our systems in their possible interactions with biopolymers) we started 

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Figure 29. Thermal melting profiles and ORD-characteristics of CT-DNA/FA-1 interactions (76, 77). (a) Melting profiles of CT-DNA (OD eo 0.625, O.OOIM NaCl, pH 7, compared with the melting characteristics of CT-DNA/FA-1 2HCI complexatiom (3 lO M aqueous solution of FA-1 2HCI ratio DNA-phosphate/FA-1 = 1/1). (b) OD-characteristics of CT-DNA/FA-1 2HCI interactions on titration. CT-DNA OD2G0 0.902, O.IM NaCl other conditions like (a).

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