Orally absorbed derivatives, cephalosporin

Cephalosporins - Hydrogenolysis of the acetoxy group in cephaloglycin (V) produced cephalexin (VI). a broad-spectrum orally absorbed cephalosporin derivative... 

CGP 9000 (9), a 3-methoxycephem derivative, is somewhat more active than cephalexin in vitro and is efficiently absorbed orally in mice.80 The structure-activity relationship of a series of orally active cephalosporins... 

Results indicate that the thienyl derivative is better absorbed orally. Series of substituted sydnone-carboxamido- and -acetamido- penicillanates and cephalos-poranates have been prepared. Various substituted isothiazole carboxamido- and acetamido- penicillanates and cephalosporanates have also been studied. Several members of the two general series have antibacterial activities comparable to clinically useful, semi-synthetic penicillins and cephalosporins. 

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