Oral leaks

Kim RB, Fromm MF, Wandel C, Leake B, Wood AJJ, Roden DM, Wilkinson GR (1998) The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV protease inhibitors. J Clin Invest 101 289-294... 

Calcium play vital role in excitation - contraction coupling in myocardium. Calcium mediates contraction in vascular and other smooth muscles. Calcium is required for exocytosis and also involved in neurotransmitters release. Calcium also help in maintaining integrity of mucosal membranes and mediating cell adhesions. Hypercalcemia may occur in hyperthyroidism, vitamin D intoxication and renal insufficiency, which can be treated by administration of calcitonin, edetate sodium, oral phosphate etc. Hypocalcemia may occur in hypothyroidism, malabsorption, osteomalacia secondary to leak of vitamin D or vitamin D resistance, pancreatitis and renal failure. Hypocalcemia can be treated by chloride, gluconate, gluceptate, lactate and carbonate salts of calcium. 

Dresser GK, Bailey DG, Leake BF, et al. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 2002 71(l) ll-20. 

Blaauw AA, I unissen KM, Cheriex EC, Wolters J, Kootstra G, Van Hooff JP. Disappearance of pulmonary capiUary leak syndrome when intravenous cyclosporine is replaced by oral cyclosporine. Transplantation 1987 43(5) 758-9. 

Dental amalgam restorations leak small amounts of elemental mercury vapor into the oral cavity of the mouth. The released mercury can be taken up by the saliva and then distributed to various organs and compartments throughout the body. Daily mercury uptake rates from amalgam are estimated to range from 2 to 25 pg Hg/24 h with the worst case individual estimated to have an uptake of 70 pg Hg/24 h. Mercury is a known neurotoxicant and the off-gassing of mercury over time may cause dementia like conditions in some people. 

Stout prisms from water, dee 240-250 slight acid taste Slightly sol in water, freely sol in solos of alkalies and alkali arbnnates Stable Bt ordinary temps MLD in rabbits, cals fmg/kgV 125-ISO. I SO-175 orally (Anderson, Leake) Caluum salt (with hexosediphosphom. and). Rcalphent Bismuth salt. JEHsIm-ol. 

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