Optimum contour diagram

Point M in the figure is the optimum that by one definition of the research problem objective should be determined. Each intersection line in the plane is a line of constant response values and is called contour lines-contour diagram. 

When the response of an analytical system depends on two factors which are continuous variables, the relationship between the response and the levels of the two factors can be represented by a surface in three dimensions as shown in Figure 7.4. This surface is known as the response surface, with the target optimum being the top of the mountain. A more convenient representation is a contour diagram (Figure 7.5). Here the response on each contour is constant, and the target optimum is close to the... 

Figure 21. Mutant space high-value contour near local optimum. Diagram is multiply branched tree with different macromolecular sequences at vertices. Each line joins neighboring sequences whose values are within 0.5 of locally optimum sequence at lower center for linearized fitness function of type 2 [Eqn. (IV.7)] and reference fold that is cruciform, like tRNA, for sequence of length 72. Over 1300 branches shown extending up to 10 mutant shells away from central optimum. Better sequence (labeled optimum) was found in tenth mutant shell. Non-random sampling of mutant sequences demonstrated typical of population sampling in quasispecies model. Note small number of ridges that penetrate deeply into surrounding mutant space. (Additional connected paths due to hypercube topology of mutant space not shown.)...

The compositional dependence of the biological response may therefore be understood by viewing iso-Ig contours superposed onto the ternary diagram (see Fig. 13.4). The cohesion strength of the glass-tissue interface will be a function of the surface area, thickness, and stiffness of the inerfacial zone and is optimum for /g 4 (Hench, 1996). 

The composition of mixed mobile phases for ternary or quaternary isoselective gradient elution can be optimized using overlapping resolution mapping strategy to adjust optimum separation selectivity based on seven or more initial experiments with solvent mixtures of approximately equal elution strengths. Based on the retention data from the initial experiments, either 3-D diagrams or contour resolution... 

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