Optimized Reaction Conditions for the HNL-Catalyzed Formation of Chiral Cyanohydrins

OPTIMIZED REACTION CONDITIONS FOR THE HNL-CATALYZED FORMATION OF CHIRAL CYANOHYDRINS 

For practical applications of HNLs as catalysts for the preparation of chiral cyanohydrins, three objectives have been achieved first, to get high enantioselec-tivity it is decisive to suppress the non-enzymatic addition of HCN to the substrate  

Recently, the use of ionic liquids instead of organic solvents has been published for the biphasic system. For PaHNL and SbHNL, the reaction rates are increased in comparison to organic solvents without a change of enantioselectivity.  

Synthesis of optically active cyanohydrins using almond meal 

During the last years, the overexpression of MeHNL and HhHNL has been improved considerably so that large quantities of these enzymes are now cheaply available. 

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