Optical rotatory dispersion synthesis

Azetidine, 7V-bromo-, 7, 240 Azetidine, AT-r-butyl- N NMR, 7, 11 Azetidine, AT-t-butyl-3-chloro-transannular nucleophilic attack, 7, 25 Azetidine, 3-chloro-isomerization, 7, 42 Azetidine, AT-chloro-, 7, 240 dehydrohalogenation, 7, 275 Azetidine, 7V-chloro-2-methyl-inversion, 7, 7 Azetidine, 3-halo-synthesis, 7, 246 Azetidine, AT-halo-synthesis, 7, 246 Azetidine, AT-hydroxy-synthesis, 7, 271 Azetidine, 2-imino-stability, 7, 256 Azetidine, 2-methoxy-synthesis, 7, 246 Azetidine, 2-methyl-circular dichroism, 7, 239 optical rotatory dispersion, 7, 239 Azetidine, AT-nitroso-deoxygenation, 7, 241 oxidation, 7, 240 synthesis, 7, 246 Azetidine, thioacyl-ring expansion, 7, 241 Azetidine-4-carboxylic acid, 2-oxo-oxidative decarboxylation, 7, 251 Azetidine-2-carboxylic acids absolute configuration, 7, 239 azetidin-2-ones from, 7, 263 synthesis, 7, 246... 

Other methods have also been used, including optical rotatory dispersion, circular dichroism (CD), and asymmetric synthesis (see p. 147). 

In the course of their studies of pseudouridine,164 Asbun and S. B. Binkley183 reported the synthesis of 5-/3-D-arabinofuranosyl- and 5-/3-D-xylofuranosyl-uracil (258 and 259) by the acid-catalyzed ring-closure of the corresponding alditol derivatives. The configuration at the anomeric carbon atom was determined on the basis of optical rotatory dispersion studies. 

Other methods have also been used for determining absolute configuration in a variety of molecules, including optical rotatory dispersion, circular dichroism, " and asymmetric synthesis (see p. 166). Optical rotatory dispersion (ORD) is a measurement of specific rotation, [a], as a function of wavelength. The change of specific rotation [a] or molar rotation [[Pg.160]

F. I. Carroll and R. Meek, Synthesis and optical rotatory dispersion studies of (S)-5-(2 -pentyl)barbituric acid derivatives, /, Org. Chem., 34 2676-2680 (1969). 

Stan s some one hundred articles dealt with the synthesis, structure, stereochemistry, and biological properties of coordination compounds, including the anticancer activity of platinum complexes optical rotatory dispersion circular dichroism the Pfeiffer Effect in metal complexes inorganic nomenclature and the application of computer techniques to chemical and information problems. A prominent educator, he edited three books on inorganic and coordination chemistry. 

The trithiocarbonates may prove useful as intermediates for the synthesis of sugar dithiols from epoxides. Ring opening by reductive cleavage with lithium aluminum hydride gives excellent results with aliphatic and ahcyclic trithiocarbonates. When both carbon atoms are secondary, the product is a iraws-dithiol for example, cyclohexene oxide, which is converted into a irans-trithiocarbonate, gives, on reduction, cyclo-hexane-1,2-dithiol. The reaction has been used in the cyclitol series for the preparation of 1,2-dithio-neo-inositol and 1,2-dithio-ir-inositol, from 1,2-anhydro-alZo-inositol. The inositol trithiocarbonates show pronounced Cotton effects in their optical rotatory-dispersion spectra. 

The demonstration of the optical activity of octahedral complexes was important in confirming Alfred Werner s intuitive ideas about coordination chemistry. Early work involved the resolution of complexes characterized by optical rotations. Modem instmments for optical rotatory dispersion were developed first, but circular dichroism (CD) spectra proved to be more useful. CD has been a powerful tool for detailed studies of the stereochemistry of octahedral complexes. Contributions to rotational strength of chelate ring conformational, configurational, and vicinal contributions are additive. Chiral metal complexes are now used in enantioselective synthesis of chiral pharmaceuticals. 

---