Optical Resolution with Carane-3,4-Diol

As a result, the ester (24) of (IS,3R,4R,6R)-carane-3,4-diol (23) with (1 /(.S W/Y/n.s-chrysanthemic acid could easily be separated by silica gel column chromatography to give two ester diastereomers. The Rf value of the ester of 

Optical resolution methods with carane-3,4-diol are noteworthy for wide generality. Esters of various cyclopropane carboxylic acids with (1,S, 3A ,4A ,6A )-carane-3,4-diol were prepared and all (lR)-isomers could easily be obtained by a simple silica gel column chromatography. 

2 Optical Resolution with 1,1 -Binaphthol Monoethyl Ether 

(1 A S Hra/7.v-chrysanthemic acid was condensed with 1,1 -binaphthol derivative using the TsCb/V-methylimidazole reagent to give the corresponding two sets of diastereomers (26) and (27). From the solution, only the (l/ )-trans-chrysanthemic acid ester (26) crystallized from the diastereomer mixtures. The ester was readily 

3 Enzymatic Resolution of (lR)-trans-Chrysanthemic Acid with Bacterium 

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Scheme 2 Optical resolution with /-menthol and carane-3,4-diol...

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