Optical imaging, gene expression

Bhaumik S, Gambhir SS. Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc Natl Acad Sci USA 2002 99 377-382. 

Wu JC, Sundaresan G, Iyer M, Gamhhir SS. Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice. Mol Ther 2001 4 297-306. 

Radionuchde-based methods, optical techniques, and magnetic resonance imaging (MRl) have each been used as platforms for gene expression imaging. Thus far, studies in the lungs have almost exclusively been limited to radionucUde-based methods. 

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