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Opioids methadone

The previous edition of this book contained a detailed description of abuse of the antiemetic tablet preparation cyclizine by illicit drug users, nearly always crushed and injected along with methadone tablets or ampoules. Cyclizine is a constituent of Diconal along with the opioid dipipanone, and it seems that cyclizine has an opioid-enhancing effect which partly accounts for the particularly euphoriant property of Diconal. This could therefore be reproduced by combining cyclizine with the synthetic opioid methadone, and the intention to do this led to a wave of patients in the UK attempting to have their methadone prescribed in the ampoule or tablet form. [Pg.97]

The inappropriate or illegal use and abuse of narcotics such as heroin is a major problem in many countries. Hence, various strategies have been employed to treat people who are addicted to heroin and other opioids. Methadone is the primary pharmacological intervention used to treat opioid addiction. Methadone is a strong opioid agonist, similar in potency and efficacy to morphine. While giving an opioid to treat an opi-... [Pg.193]

Medical means of getting an addict off morphine allows withdrawal with less drastic symptoms. Methadone, legally administered through drug rehabilitation programs, can be substituted for morphine just as it is for heroin. A totally synthetic opioid, methadone lasts longer within the body than either morphine or heroin. Methadone closely mimics the basic opiate stmcture. [Pg.360]

FLECAINIDE OPIOIDS Methadone and tramadol may t flecainide levels Methadone and tramadol inhibit CYP2D6-mediated metabolism of flecainide Monitor PR and BP closely... [Pg.19]

NNRTIs ANALGESICS-OPIOIDS Methadone levels may be significantly 1 by efavirenz and nevirapine t CYP3A4- and CYP2B6-mediated metabolism of methadone Monitor closely for opioid withdrawal, t dose as necessary. Likely to need dose titration of methadone (mean 22% but up to 186% t)... [Pg.596]

ABCBl ATP-binding cassette, subfamily B, member 1 rsll28503, rsl045642, rs2032582 Opioids Methadone... [Pg.595]

ARRB2 Arrestin P -2 rs3786047, rsl045280, rs2036657 Opioids Methadone... [Pg.595]

BDNF Brain-derived neurotrophic factor rs7127507, rsl967554, rsll030118, rs988748, rs2030324, rsll030119, rs2239622 Opioids Methadone... [Pg.595]

CTP2D6 Cytochrome P450, family 2, subfamily D, polypeptide 6 Multiple (see [253]) Opioids Methadone... [Pg.595]

KCNJ6 Potassium inwardly rectifying, channel subfamily J, member 6 rs2070995 Opioids Methadone... [Pg.596]

OPRD1 8-Opioid receptor rs678849 Opioids Methadone, suboxone, buprenorphine... [Pg.596]

Methadone levels can be reduced by carbamazepine, phenobarbitai or phenytoin. See Opioids Methadone + Antiepiieptics , p.l63. [Pg.162]

For comment on the effect of enzyme inducers such as phenobarbital on opioid metabolism, see Opioids + Antiepileptics Enzyme-inducing , p.l62 and Opioids Methadone + Antiepileptics , p.l63. [Pg.165]

The SSRIs, particularly fluvoxamine, can raise methadone levels. See SSRIs + Opioids Methadone , helow. [Pg.1221]

See other pages where Opioids methadone is mentioned: [Pg.202]    [Pg.1346]    [Pg.594]    [Pg.594]    [Pg.596]    [Pg.7]    [Pg.163]    [Pg.168]    [Pg.176]    [Pg.182]    [Pg.185]    [Pg.189]    [Pg.190]    [Pg.190]    [Pg.1221]    [Pg.1222]    [Pg.128]    [Pg.130]   
See also in sourсe #XX -- [ Pg.1040 ]

See also in sourсe #XX -- [ Pg.304 , Pg.305 ]



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Methadone

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