Opioid receptors nomenclature

Opioid Nomenclature Proposal, Revised lUPHAR Opioid Receptor Nomenclature Subcommittee Proposal, International Nar-- codes Research (Conference, Seattle, WA, 2000. 

It is generally accepted that three major classes of opioid receptors exist. The most commonly used terminology discriminates between p-, K-, and 8-opioid receptors. However, after cloning of the three genes encoding opioid receptors, a new nomenclature was agreed upon OPl (corresponding to the 8 receptor), OP2 (k receptor) and OP3 (p receptor) (Dhawan et ah. 

Henderson. G. et al. (1997) The orphan opioid receptor and its endogenous ligarKl - nociceptin/orphanin FQ. Trends Pharmacol. ScL. 18.293-300. Alexander. S.P.H. er al. (1998) Receptors and ion channel nomenclature supplement. Ninth Edition. Trends Pharmacol. Sci.. Su/. . IS, 1-98. 

Discovery of Multiple Opioid Receptor Types and Current Nomenclature, 341... 

Generally, there exist three main categories of the "opioid receptors, namely a) mu (p) kappa designated by "F and (c) delta designated by 5 . It is, however, pertinent to state here that all the aforesaid opioid receptors have been adequately eharacterized and also cloned. Based on the most reeent universally adopted and recognized nomenclature classifies the said three opioid reeeptors in the actual order by which they were eventually eloned. Aceording to this elassifieation the various reeeptors are commonly termed as follows ... 

There are the three major types of opioid receptors p, k (13), and 5 (14). All three of the receptor types have been well characterized and cloned (15). A nomenclature adopted by the International Union of Pharmacology (lU PHAR) in 1996 classifies the three opioid receptors by the order in which they were cloned (16). By this classification, 5 opioid receptors are OPi receptors, k opioid receptors are OP2 receptors, and p opioid receptors are OP3 receptors. The lUPHAR approved a new nomenclature in 2000, naming the receptors as MOP-p, DOP-5, and KOP-k. In current literature, however, the opioid receptors often are referred to as DOR (5), KOR (k), and MOR (p). There is evidence for subtypes of each of these receptors however, the failure of researchers to find genomal evidence for... 

Note on receptor nomenclature Opioid receptors, originally called 6, k, and p receptors, are also referred to as OP2, OP2, and OP3 receptors, or DOR, KOR, and MOR receptors respectively. 

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