Operational genes

The activity of the operator gene is controlled by the regulator gene (i), which produces a specific protein, the repressor. The repressor protein can com-... 

Figure 13.1 Operon model for control of protein synthesis. The example chosen is the lactose (lac) operon. I, regulatory gene p, promoter site o, operator gene z, y, and a represent the structural genes for j8-galactosidase, permease, and transacetylase, respectively.

In end-product repression (see later), it was postulated that the repressor protein is inactive until it binds the repressing metabolite (corepressor) to form an active repressor-corepressor complex that can combine with the operator gene to block synthesis at the operon. 

GAL81 operator gene for GALA permits constitutive synthesis of enzymes controlled by GALA 342... 

However, not all the results in glycogen storage disease can be dismissed as resulting from imperfect laboratory technique. Enzyme deficiencies could occur if the mutation was in an operator gene controlling more than one adjacent gene (Jl), and it is not impossible that such a situation exists in the hereditary metabolic errors of urea formation. 

Note that the repressor product of each Rv w.d.+ acts indifferently on each target operator gene, and that the effector substance produced by each structural gene series is indistinguishable in its ability to block the repressor activity of R +. 

Sadler JR, Tecklenburg M, Betz JL. Plasmids containing many tandem copies of a synthetic lactose operator. Gene 1980 8 279-300. 

Since R. rubrum is prokaryotic, this could be explained with operon hypothesis. As shown in Fig. 2, the expression product of regulating gene, the repressor, binds with the operating gene, so that " theRNA polyme -... 

Regulator gene Operator gene Structural gene... 

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