Open reading frames genomes

A human cDNA expression library in yeast enriched for open reading frames. Genome Res. 11, 1730-1735. 

As the complete genomes of more and more species are sequenced, the determination of the function of previously unidentified open reading frames is becoming an increasing and challenging problem. The possibility of... 

Figure 2. Restriction map of the A. aculeatus rhgA genomic clone plM803. pIM803 contains a 3.9-kb chromosomal Ba/nHI-Sa/1 fragment in pBluescriptSK(-l-). The open reading frame is indicated as closed bars. 5 - and 3 - untranslated sequences and introns are given as open boxes.

A well accepted meaning for the term functional genomics has been the research activities leading to the identification of the function of open reading frames (ORF) in complete genome sequences. The focus is on the particular ORFs that have no similarity to other sequences of known function and that, if removed from the... 

The number of genes annotated in this genome is unusually large given the genome size. Thus we suspect that many of the annotated open reading frames are not real genes, which results in an unexpectedly low rate of fold prediction. 

Bonaldo, M.F., Bair, T.B., Scheetz, T.E., et al. (2004) 1274 EuU-open reading frames of transcripts expressed in the developing mouse nervous system. Genome Res., 14, 2053-2063. 

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