One-variable-at-a-time method

In the optimization of tablet formulations, different approaches can be used. The one variable at a time method requires many experiments and there is no guarantee that an optimal formulation is achieved. Moreover the interaction between different factors, which may influence the tablet properties, will not be detected [10]. The use of an experimental design can be helpful in the optimization of tablet formulations. Mixture designs can be used to describe the response (tablet properties) as a function of the... 

The traditional approach to the optimization problem is the one-variable-at-a-time method. In this process, all variables but one are held constant and the optimum level for this variable is determined. Using this... 

The evaluation of sensitivities can be accomplished in a number of ways, and there are many different methods and computer codes available (see, e.g., Refs. [8,33] and references cited therein). The simplest among them is the brute-force or one-variable-at-a-time method the model response, rij, is computed by changing the value of a given model parameter, 6i, while keeping the rest unchanged and then is evaluated by equation (6). A newcomer to kinetic modeling is advised to begin with this simple brute-force approach. First, it is easy to use since hardly any additional... 

---