NMR spectroscopy one-dimensional

NOESY NMR spectroscopy is a homonuclear two-dimensional experiment that identifies proton nuclei that are close to each other in space. If one has already identified proton resonances in one-dimensional NMR spectroscopy or by other methods, it is then possible to determine three dimensional structure through NOESY. For instance, it is possible to determine how large molecules such as proteins fold themselves in three-dimensional space using the NOESY technique. The solution structures thus determined can be compared with solid-state information on the same protein obtained from X-ray crystallographic studies. The pulse sequence for a simple NOESY experiment is shown in Figure 3.23 as adapted from Figure 8.12 of reference 19. 

In most cases, structural characterization of carbosilane dendrimers is accomplished by multinuclear one-dimensional NMR spectroscopy (1H, 13C and 29Si). However, as larger dendrimers are characterized standard spectroscopic methods become less useful due to the overlap of signals. This problem has been elegantly circumvented as described in a recent paper by Tessier, Rinaldi and coworkers56. In this paper the researchers described the use of 1 H/13C/29Si triple resonance, 3D and pulse field gradient NMR techniques to... 

Figure 6-1 The pulse arrangements for a single cycle of one-dimensional NMR spectroscopy (top) and for two-dimensional NMR correlation spectroscopy (COSY)...

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