Thiopental Ondansetron

Metoclopramide pre-treatment reduces the dosage requirements of propofol and thiopental. Droperidol, but not ondansetron, reduces the dose requirements of thiopentaL... 

In a double-blind, placebo-controlled, randomised study of 168 female patients ondansetron 100 or 200 micrograms/kg given intravenously 5 minutes before thiopental induction did not influence the hypnotic requirements of the thiopental. ... 

Although the evidence is limited these interactions between metoclopramide and thiopental or propofol, and between droperidol and thiopental would appear to be established. Droperidol has not been studied with propofol, but, on the basis of other interactions it would be expected to behave like metoclopramide. When patients are pretreated with either metoclopramide or droperidol, be alert for the need to use less propofol and thiopental to induce anaesthesia. Ondansetron appears not to interact. 

Kostopanagiotou G, Pouriezis T, Theodoraki K, Kottis G, Andreadou I, Smymiotis V, Pa-padimitriou L. Influence of ondansetron on thiopental hypnotic requirements. J Clin Pharma-co/(1998) 38, 825-9. 

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See also in sourсe #XX -- [ ]

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