Once Established, Life Is to Remain Present in This Universe

Once Established, Life Is to Remain Present in This Universe 

Wnt receptors frizzled are activated by both LRP5/6 and P-catenins. Some of the dickkopf proteins (DKKl/2/4) bind LRPs (lipoprotein receptor-related protein), thus to inhibit Wnt pathway activation. Many MDA (M.D. Anderson) established breast cancer cell lines (vide infra) express both cytoplasmic and intranuclear P-catenin and DKKl this combination in triple negative breast cancer was foretelling a bad prognosis. In contrast, DKK3 inhibited the proliferation and invasiveness of endometrial carcinoma cells [818-821]. 

The ctenophores operate a physiologically deviant Wnt pathway without axin, thus promoting P-catenin s intranuclear transfer further, the inhibitory dickkopf protein is also absent. These cells are physiologically functioning as if malignantly transformed , like colon cancer cells (see in the Appendix 1). 

APOBEC family apolipoproteinB mRNA-editing enzyme catalytic. Inhibits LINE (long interspersed nucleotide elements) retrotransposition in vertebrates. (Click for RNA-editing enzymes in LindiC N et al Chair Biochemistry Faculty Chemistry Chemical Technology University Ljubljana, Ljubljana, Slovenia). 

---