Omeprazole Tripotassium dicitratobismuthate

TRIPOTASSIUM DICITRATOBISMUTHATE PROTON PUMP INHIBITORS - OMEPRAZOLE t adverse effects of tripotassium dicitratobismuthate T absorption Do not use together for more than 16 weeks. Bismuth salicylate and subnitrate do not interact... 

Omeprazole markedly increases the absorption and bioavailability of bismuth from tripotassium dicitratobismuthate and bismuth biskalcitrate. Other proton pump inhibitors are expected to interact similarly. However, this is probably unlikely to be clinically relevant. 

In an earlier single-dose study in 6 healthy subjects, a single 240-mg dose of tripotassium dicitratobismuthate was taken 1 hour after the last dose of a 1-week course of omeprazole 40 mg daily. Omeprazole increased the AUC of bismuth fourfold, and increased the maximum serum levels from 36.7 to 86.7 micrograms/L, which the authors pointed out approaches the considered toxic range for bismuth (100 micrograms/L and above). 

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