Omeprazole-based fast follower

The following discussion will be centered on the application of the strategies and approaches for enzymatic stability improvement and p Tg fine-tuning, to improve the druggability for the omeprazole-based fast followers. The strategy of reformulating the omeprazole to overcome the solution instability issue associated with the original launched omeprazole can be found in other published reviews. 

In summary, the omeprazole-based fast follower approaches identified key liabilities associated with omeprazole and put forward medicinal chemistry and formulation strategies to address these potential liabilities. The tactics used in addressing these points involved the following ... 

---