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Oligosaccharyl transferase

Fig. 3. Representative pathway for the biosynthesis of Asn-linked oligosaccharide. Biosynthesis starts in the rough endoplasmic reticulum and proceeds through the cis-, medial-, and trans-Golgi apparatus, before glycoprotein is secreted. Some of the enzymes involved are oligosaccharyl transferase (OST) a-glucosidase I II (aG I II) ER-mannosidase (aM) a-mannosidase I II (aM I II) N-acetylglucosaminyl transferase I II (GnT I II) fucosyl transferase (FucT) galactosyl transferase (GalT) sialyl transferase (ST). n-Gn O-Man -Glc V-Fuc A-Gal O-SA (adopted from [40])... Fig. 3. Representative pathway for the biosynthesis of Asn-linked oligosaccharide. Biosynthesis starts in the rough endoplasmic reticulum and proceeds through the cis-, medial-, and trans-Golgi apparatus, before glycoprotein is secreted. Some of the enzymes involved are oligosaccharyl transferase (OST) a-glucosidase I II (aG I II) ER-mannosidase (aM) a-mannosidase I II (aM I II) N-acetylglucosaminyl transferase I II (GnT I II) fucosyl transferase (FucT) galactosyl transferase (GalT) sialyl transferase (ST). n-Gn O-Man -Glc V-Fuc A-Gal O-SA (adopted from [40])...
Figure 5.57 Structure of the tetradecasaccharide donor substrate of oligosaccharyl transferase. Figure 5.57 Structure of the tetradecasaccharide donor substrate of oligosaccharyl transferase.
Sharma, C.B., Lehle, L. Tanner, W. (1981) N-Glycosylation of Yeast Proteins. Characterization of the Solubilized Oligosaccharyl Transferase , European Journal of Biochemistry, 116,101-8... [Pg.335]

Signal peptidase Prolyl 4-hydroxylase Prolyl 3-hydroxylase Lysyl hydroxylase Hydroxylysyl galactosyl-transferase Hydroxylysyl glucosyMransferase Oligosaccharyl transferase Protein disulphide isomerase Prolyl-peptidyl cis/trans isomerase BiP... [Pg.1513]

Figure 3.1 Inhibitors of yeast oligosaccharyl transferase show the preference for glycosyl hydrazides over natural linkage. Figure 3.1 Inhibitors of yeast oligosaccharyl transferase show the preference for glycosyl hydrazides over natural linkage.
Figure 1. Initial steps in protein N-glycosylation. Pre-assembly of oligosaccharide-P-P-Dol and en bloc transfer to the protein in the endoplasmic reticulum. Dol, dolichol OST, oligosaccharyl-transferase P, phosphate , GlcNAc O, Man A, Glc. Figure 1. Initial steps in protein N-glycosylation. Pre-assembly of oligosaccharide-P-P-Dol and en bloc transfer to the protein in the endoplasmic reticulum. Dol, dolichol OST, oligosaccharyl-transferase P, phosphate , GlcNAc O, Man A, Glc.
As has been mentioned earlier in this chapter, oligosaccharyl dolichol is a substrate for oligosaccharyl transferase, generating glycoprotein and dolichyl pyrophosphate [2], The latter is hyrolyzed by a phosphatase, regenerating dolichyl phosphate for use in subsequent assembly cycles [49]. The level of dolichyl phosphate is clearly important in the regulation of the amount of assembly of oligosaccharyl dolichol that occurs [7, 50]. [Pg.1165]

Oligosaccharyl dolichol is the major dolichol form in growing cells, with DPM, GPM, dolichol, and dolichyl phosphate being present in lower amounts [51). Besides being a substrate for oligosaccharyl transferase, oligosaccharyl dolichol is... [Pg.1165]

See other pages where Oligosaccharyl transferase is mentioned: [Pg.145]    [Pg.314]    [Pg.353]    [Pg.365]    [Pg.365]    [Pg.391]    [Pg.90]    [Pg.3]    [Pg.160]    [Pg.659]    [Pg.1212]    [Pg.1736]    [Pg.1740]    [Pg.2256]    [Pg.163]    [Pg.314]    [Pg.431]    [Pg.431]    [Pg.435]    [Pg.304]    [Pg.305]    [Pg.674]    [Pg.254]    [Pg.4]    [Pg.4]    [Pg.75]    [Pg.75]    [Pg.7]    [Pg.12]    [Pg.1160]    [Pg.1165]    [Pg.2052]   
See also in sourсe #XX -- [ Pg.11 , Pg.11 , Pg.37 , Pg.147 ]



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