Oligosaccharides derivatizing agents

In complex matrices, the insufficient specificity at 200 nm and the low sensitivity of direct UV detection make the analysis of carbohydrates more difficult. Therefore, derivatization of carbohydrates with a suitable agents is still a preferred approach for the detection of monosaccharides and oligosaccharides. Derivatization agents like 2-aminopyridine, 8-aminonaphthalein-l,3,6-trisulfonate (ANTS) or 8-aminopyren-l, 3,6-trisulfonate... 

Rohmer, M. Meyer, B. Mank, M. Stahl, B. Bahr, U. Karas, M. 3-Aminoquinoline Acting as Matrix and Derivatizing Agent for MALDI MS Analysis of Oligosaccharides. Anal. Chem. 2010,52,3719-3726. 

Naturally occurring oligosaccharides including disaccharides and trisaccharides have attracted enormous attention in the last few years. Multidisciplinary efforts of biochemists and medicinal chemists have led to new developments [1,2,3,4,5] in the field, which are based primarily on the phenomenal physical properties such as stability, crystallinity, and solubility. Chemical properties include selective reactivity towards various reagents such as oxidative and reducing agents and this has opened up new possibilities for functionalization and derivatization of value-added oligo- and polysaccharides. 

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