Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Oligonucleotides, stability duplex melting

In addition to the base-pairing disruption, this melting also destroys the stacking of bases in fixed orientations relative to one another that is observed in the duplex. Later, we will present an argument based upon thermodynamic measurements of the stabilities of synthetic oligonucleotides (small pieces of synthetic nucleic acids) that the next-nearest neighbor interactions observed in the base stacking sequence are a major contributor to the relative stabilities of duplexes. [Pg.233]

Reactions (16.24) and (16.25) show the two possible duplex structures associated with the oligonucleotide, d(CGCGAATTCGCG). Optical and calorimetric studies of the melting of this duplex were conducted at various salt (NaCl) and oligonucleotide concentrations to gain information about the relative stabilities of the two structures. The results of these studies are summarized in Table 16.3. [Pg.255]

See other pages where Oligonucleotides, stability duplex melting is mentioned: [Pg.247]    [Pg.260]    [Pg.131]    [Pg.152]    [Pg.247]    [Pg.260]    [Pg.220]    [Pg.384]    [Pg.399]    [Pg.435]    [Pg.194]    [Pg.287]    [Pg.822]    [Pg.261]    [Pg.68]    [Pg.56]    [Pg.549]    [Pg.225]    [Pg.642]    [Pg.131]    [Pg.1800]    [Pg.719]    [Pg.208]    [Pg.221]    [Pg.205]    [Pg.209]    [Pg.209]    [Pg.213]    [Pg.207]    [Pg.219]    [Pg.642]    [Pg.261]    [Pg.248]    [Pg.260]    [Pg.37]    [Pg.47]    [Pg.60]    [Pg.153]    [Pg.254]    [Pg.65]    [Pg.227]    [Pg.207]    [Pg.513]    [Pg.377]    [Pg.186]   
See also in sourсe #XX -- [ Pg.7 , Pg.250 ]



SEARCH



DUPLEX

Duplexe

Duplexer

MELT STABILITY

Melt stabilizers

Oligonucleotides, stability

© 2024 chempedia.info