Oligonucleotide sulfoxides

Poly(ether thioether)s, poly(ether sulfoxide)s or PES nucleic acids have been suggested as mimics, for natural materials, i.e., with the action of an antisense oligonucleotide. The backbone may bear a plurality of ligands including naturally occurring nucleobases. 

Oligonucleotide Analogs with DimethylenesuMde, -sulfoxide, and -sulfone Groups Replacing Phosphodiester Linkages... 

Schaller, H, Weimann, G, Lerch, B, and Khorana, H G (1963) Studies on polynucleotides XXIV. J. Am. Chem. Soc. 85,3821-3827 Schneider, K. C. and Benner, S A (1990) Building blocks for oligonucleotide analogs with dimethylene-sulfide, -sulfoxide, and -sulfone groups replacing phosphodiester linkages. Tetrahedron Lett. 31, 335-338. 

K.C. Schneider and S.A. Benner, Building blocks for oligonucleotide analogs with dimethylene-sulfide, -sulfoxide, and -sulfone groups replacing phosphodiester linkages. Tetrahedron Lett. 31 335 (1990). 

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