Oligonucleotide-mediated mismatch

There are many publications describing oligonucleotides conjugated to various metals, the most common of which is attachment to gold nanoparticles or gold electrodes. There are also many reports on metal-mediated base pairs that are discussed in detail in section 1.2.3 rather than in this section, but include the known stabilisation of a C C mismatch with Ag(l) ions and T T mismatches stabilised by Hg(ll) ions. The other major metal conjugate that has been described is platinum due to its known cytotoxicity and use as an anti-tumor agent. 

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