Oligolamellar vesicles

Hydration of Phospholipids with Solutions of Very Low Ionic Strength Very large unilamellar and oligolamellar vesicles can be prepared when a thin lipid film is dispersed in a solution of very low ionic strength (Reeves and Dowben, 1969). The formation of vesicles with diameters up to 300 pm enclosing latex beads with a diameter of 20 pm have been reported (Antanavage et al., 1978). 

Liposomes consist of many phospholipid bilayers of only few, or just one bilayer (Fig. 5). Therefore multilamellar vesicles (MLV), oligolamellar vesicles (OLV), small unilamellar (SUV), and large unilamellar vesicles (LUV) have to be distinguished. Furthermore, multivesicular liposomes (MVL) may be formed. 

Oligolamellar vesicles and LUV Homogenization of MLV with liposome extruder and polycarbonate membranes of defined pore size Heterogeneous vesicle mixture requires specialized equipment... 

The high entrapment capability of DRV s is due to the fact that preformed empty small unilamellar vesicles are disrupted during a freeze-drying cycle in the presence of the solute destined for entrapment. Subsequently, during controlled rehydration, which is carried out in the presence of a concentrated solution of the solute (to be encapsulated), the vesicles fuse into large oligolamellar... 

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