Oleaginous vehicles

Marcato, B., Guerra, S., Vianello, M. and Scalia, S. (2003). Migration of antioxidant additives from various polyolefinic plastics into oleaginous vehicles, Int. J. Pharm., 257, 217-225. 

The U.S. Pharmacopoeia (USP) classifies injections into five different types. The dosage form selected for a particular drug product is dependent upon the characteristics of the drug molecule (e.g., stability in solution, solubility, and injectability), the desired therapeutic effect of the product (e.g., immediate vs. sustained release), and the desired route of administration. Solutions and some emulsions (e.g., miscible with blood) can be injected via most parenteral routes of administration. Suspensions and solutions that are not miscible with blood (e.g., injections employing oleaginous vehicles) can be administered via intramuscular or subcutaneous injection but should not be given intravenously. 

Emollient oleaginous vehicle skin penetrant solvent. 

Emollient oleaginous vehicle solvent tablet and capsule lubricant therapeutic agent. 

Allen LV. Featured excipient oleaginous vehicles. Int J Pharm... 

Injectable preparations are usually either sterile suspensions or solutions of a drug in water or in a suitable vegetable oil. Solutions act faster than drugs in suspensions with an aqueous vehicle, providing faster action than an oleaginous vehicle. Drug absorption occurs... 

C. is used mainly in the food industry (cooking and salad oil, dressings). It is hydrogenated for margarine production. There are also some applications in cosmetics and pharmaceuticals (as oleaginous vehicle). 

Sesamine, a complex cyclic ether and sesamiline, a glycoside, are antioxidants present in small amounts. S. is slightly miscible in alcohol and soluble in carbon disulfide, chloroform, ether and petroleum ether it is insoluble in water and is used in pharmaceutical formulations as a solvent and oleaginous vehicle. It is widely used as an edible oil and for the manufacture of margarine. 

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