6-OHDA-induced neuronal death

Levites Y, Youdim MB, Maor G, Mandel S. 2002b. Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures. Biochem Pharmacol 63 21-29. 

In summary, the 6-OHDA model does not mimic all pathological and clinical features of human Parkinsonism. It induces DA neuron death, whereas the formation of cytoplasmatic inclusions (LB) does not occur. However, these models are very useful for testing cell replacement therapies or neuroprotective treatments. 

As stated above, our system should also allow for the identification of genes involved in 6-OHDA-induced DA neuron degeneration and cell death pathways reminiscent of PD. The two main types of cell death that can occur during normal development and disease are apoptosis and necrosis (121,122). Both forms of cell death are morphologically distinct. Apoptosis results in cell shrinkage, nuclear fragmentation, and the formation of apoptotic bodies, whereas necrosis... 

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