Probenecid Ofloxacin

PROBENECID QUINOLONES -CIPROFLOXACIN, LEVOFLOXACIN, NALIDIXIC ACID, NORFLOXACIN t ciprofloxacin, nalidixic acid and norfloxacin levels Uncertain Watch for t incidence of side-effects. Moxifloxacin, ofloxacin and sparfloxacin do not seem to interact and could be used as alternative therapy... [Pg.485]

Probenecid increases the serum ieveis and/or decreases the urinary excretion of cinoxacin, ciprofloxacin, clinafloxacin, enoxacin, fleroxacin, levofloxacin, nalidixic acid and norfloxacin. The ciinicai importance of these changes is uncertain, but is seems iikeiy they wiii oniy be important in the presence of other drugs that aiso affect renai excretion. Grepafloxacin, moxifloxacin, sparfloxacin, and probably ofloxacin, appear not to interact with probenecid. [Pg.340]

A study in 8 healthy subjects found that probenecid 500 mg increased the AUC of a single 200-mg dose of ofloxacin by 16% and decreased the total body clearance by 14%. Other pharmacokinetic parameters were not significantly affected. ... [Pg.340]

Nataraj B, Rao Mamidi NVS, Krishna DR, Probenecid affects the pharmacokinetics of ofloxacin in healthy volunteers, Clin Drug Invest (199S) 16, 259-62,... [Pg.341]

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