Ofloxacin dosage

Ofloxacin Dosage Guidelines (Oral and IV)-Infection Description Dose Frequency Duration... 

Ofloxacin Dosage in Impaired Renal Function Ccr (mL/min) Maintenance dose Frequency... 

Ofloxacin - Maximum serum concentrations are achieved 1 to 2 hours after an oral dose. Steady-state concentrations are achieved after 4 doses. Ofloxacin is widely distributed to body tissues and fluids. Elimination is mainly by renal excretion 4% to 8% is excreted in the feces. A longer plasma half-life of about 6.4 to 7.4 hours was observed in elderly subjects, compared with 4 to 5 hours for young subjects. Dosage adjustment is necessary for patients with impaired renal function (Ccr 50 mL/min or less). 

Hepatic function impairment There are no data in patients with severe cirrhosis. Dosage adjustment is recommended in patients with mild-to-moderate cirrhosis. Eideriy Norfloxacin is eliminated more slowly because of decreased renal function. The apparent half-life of ofloxacin is 6 to 8 hours, compared to approximately 5 hours in younger adults. Lomefloxacin plasma clearance was reduced by 25% and the AUC was increased by approximately 33% in the elderly. 

The increased levels and decreased renal excretion of clinafloxacin caused by probenecid are not considered large enough to warrant dosage adjustment," and most of the changes seen with the other quinolones were of a similar magnitude. However, caution has been advised in the presence of other drugs that may also compete for renal excretion (such as some penicillins or cephalosporins). " Grepafloxacin, moxifloxacin, sparfloxacin, and probably ofloxacin, appear not to interact. 

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