Compounds of Germanium

I. THE METHYLATION OF GERMANIUM COMPOUNDS UNDER ENVIRONMENTAL OR MODEL ENVIRONMENTAL CONDITIONS A. Methods of Analysis... 

FIGURE 2. Depth profile of germanium compounds in Baltic Sea (modified from Reference 11) MeGe, monomethylgermanium Me2Ge, dimethylgermanium Asi, total dissolved inorganic arsenic... 

Since plants used as herb medicines contain high amounts of germanium compounds, the latter have been regarded as having immunopotentiation and antitumour activities. At present, organogermanium compounds are mainly used for medical applications. For example, Ge-132 is well known to have not only an antitumour effect, but also to induce interferon (IFN) production in vivo8. 

Gerber GB, Leonard A Mutagenicity, carcinogenicity and teratogenicity of germanium compounds. Ret 387(3) 141-146, 1997... 

The stereochemical data reported in the case of germanium compounds by Eaborn et al. 90), Brook and Peddle 91), or Carre and Corriu (92) are quite parallel to those discussed here. The nature of the leaving group and the electronic character of the nucleophile, rationalized in terms of hard and soft reagents, are also the dominant factors that govern the stereochemistry. 

Nitroxyl chloride, 4 52 Nitryl chloride, 4 52 Nomenclature, of germanium compounds, 5 64... 

The biological activity of germanium compounds and their influence on the biosphere have been considered in detail in an excellent monograph of Latvian and Russian chemists published in 1990 (in which 767 references are cited86) as well as in earlier reviews by... 

Davydov, V. I. (1966). Germanium. New York Gordon and Breach. A translation of a Russian book that contains a great deal on the discussion of the physical chemistry of germanium compounds. 

A series of germanium compounds 459a-c stabilized by 2,6-bis(dialkylaminomethyl)-4-(f-butyl)phenyl tridentate ligand was recently obtained (equation 78) . Their Si analogues Si-459a and Si-459d (R = H, R = Me, R = CH=CH2) were analogously prepared. 

The synthesis and reactivity of germanium compounds containing double bonds to Si, Ge, and Sn has been a very active area of research over the past decade and has been extensively and recently reviewed. Particularly striking... 

Uses. — Recently some success has been met in the treatment of anemia by means of germanium compounds. ... 

UghiyamaT, Nakai S, Chittrakarn S, Chang HS and Kato N (1993) Toxicity and tissue accumulation of germanium compound. Biomed Res Elements 4 125-126. 

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