OECD test

There have been numerous communications on the subject of biodegradation test methods, including aerobic compost (30), anaerobic bioreactor (31), general methodology and future directions (32—34), and a fine review article (24). ASTM (22) and MITI (35) have also set forth standard testing protocols for plastics, as shown in Table 2, whereas OECD test methods (29) are more suited to water-soluble polymers. 

Identification of gaps in existing OECD Test Guidelines for these endpoints. 

D]ata generated in the testing of chemicals in an OECD Member country in accordance with OECD Test Guidelines and OECD Principles of Good Laboratory Practice shall be accepted in other Member countries for purposes of assessment and other uses relating to the protection of man and the environment. 

OECD. Test guideline 428 Skin Absorption In Vitro Method, OECD, Paris, 2004. 

J. Esdaile, and M. Liebsch. An evaluation of the proposed OECD testing strategy for skin corrosion. A kern. Lab. Anim. 26 709-720 (1998). 

OECD, Skin absorption in vitro method. OECD Test Guideline 428, Paris, 2004. Wagner, H., et ah. Drug distribution in human skin using two different in vitro test systems comparison with in vivo data. Pharm. Res., 17, 1475-81, 2000. 

Klein, W., Kordel, W., Weip, M., and Poremski, H.J. Updating of the OECD test guideline 107 partition coefficient-octanol/water OECD laboratory intercomparison test of the HPLC method, Chemosphere, 17(2) 361-386, 1988. Klemenc, A. and Low, M. Die Loslichkeit in Wasser und ihr Zusammenhang der drei Dichlorbenzole. Line Methode zur Bestimmung der Loslichkeit sehr wenig loslicher und zugleich sehr fluchtiger Stoffe, Rec. Trav. Chim. Pays-Bas, 49(4) 629-640, 1930. 

Cunha GCP (2005) Evaluation of mechanisms inducing thyroid toxicity and the ability of the enhanced OECD Test Guideline 407 to detect these changes. Arch Toxicol 79 390 05... 

The harmonized test guidelines have been developed for use in the testing of pesticides and toxic substances, and the development of test data that must be submitted to the US-EPA for review under Federal regulations. The OPPT guidelines are based on the OECD test guidelines (Section 2.2.6) however, minor deviations may occur. The guidelines are available for download at the OPPT Web site (US-EPA 2006d). 

The testing methods working area of the EU is closely linked and coordinated with the parallel OECD Test Guidelines program. 

---