OECD Organization for Economic Cooperation

OECD, Organization for Economic Cooperation and Development, Guideline 414, Prenatal Developmental Toxicity Study, 2001a. 

The United Nations Globally Harmonized System of Classification and Labelling of Chemicals (GHS) includes an internationally standardized guidance procedure on Transformation/Dissolution Protocol (T/DP) for metals and sparingly soluble metal compounds (United Nations, 2007), recently validated by the OECD (Organization for Economic Cooperation and Development). To establish the acute aquatic hazard classification level of a metal-bearing substance under the GHS, data from the T/DP are compared with an acute ecotoxicity reference value (ERV) derived under conditions similar to those of the T/DP. 

OECD] Organization for Economic Cooperation and Development. 2004. Manual for investigation of HPV chemicals OECD Secretariat, September 2004. Available from http // www.oecd.org/document/7/0,3343,en 2649 34379 1947463 l l l l,00.html. 

OECD] Organization for Economic Cooperation and Development. 2006a. Current approaches in the statistical analysis of ecotoxicological data a guidance to application. Paris (France) Environment Directorate OECD. OECD Environment Health and Safety Publications. Series on testing and assessment, no. 54. 147 p. 

OECD] Organization for Economic Cooperation and Development. 1992. Report of the OECD workshop on the extrapolation of laboratory aquatic toxicity data on the real environment. Paris OECD environment monographs no. 59. 

OECD (Organization for Economic Cooperation and Development). 1996. OECD Guidelines for Testing of Chemicals. Combined Repeated Dose Toxicity Study with the Reproduction/ Developmental Toxicity Screening Test. TG No. 422. Organization for Economic Cooperation and Development, Paris, France. 

Note. FHSA, Federal Hazard Substance Act NAS, National Academy of Sciences OECD, Organization for Economic Cooperation and Development IRLG, Interagency Liaison Group. Tests should be conducted on monkeys when confirmatory data are required. 

---