Octreotide Cyclosporine

Prospective, randomized trial did not show a benefit after pancreas transplantation. Octreotide lowers cyclosporine-A levels and may cause escape rejection if cyclosporine levels are not carefully monitored. Intravenous infusions of 25-50 mcg/hour have been utilized. 

A. Octreotide may inhibit the absorption of dietary fats and cyclosporine. 

Since then, both natural and unnatural cyclic peptides have become important synthetic targets because of their potential applications as antibiotics and other therapeutic agents [50-54]. Selected examples include anticancer agents (ADH-1), antibiotics (colistin), growth hormone inhibitors (octreotide), and immunosuppressant agents (cyclosporine A) (Fig. 6) [55]. 

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