Octreotide Ciclosporin

OCTREOTIDE ANTICANCER AND IMMUNOMODULATING DRUGS - CICLOSPORIN l plasma concentrations of cidosporin and risk of transplant rejection Octreotide is a strong inducer of CYP3A4-mediated metabolism of cidosporin Avoid co-administration if possible if not, monitor cidosporin levels closely... 

Octreotide causes a marked reduction in the blood levels of ciclosporin and inadequate immunosuppression may result Lan-reotide is predicted to interact similarly. 

Uncertain. A suggestion is that the octreotide reduces the intestinal absorption of the ciclosporin. ... 

The interaction between octreotide and ciclosporin is established and clinically important, although the documentation is limited. The authors of one report recommend that before giving octreotide the oral dosage of ciclosporin should be increased on average by 50% and the serum levels monitored daily. The manufacturers of lanreotide say that, as with other somatostatin analogues, it may reduce the absorption of ciclosporin from the gut. As yet there appear to be no reports of this interaction in practice however, it would be prudent to monitor the outcome of the use of lanreotide with ciclosporin. 

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