Obstructive sleep apnea case study

In a study of 54 996 children (almost 200 000 patient-years of follow-up) enrolled in the National Cooperative Growth Study (NCGS) concerns were raised to the risk of sudden death [28 ]. Two of 511 patients with Prader-Willi syndrome died suddenly within 6 months of starting growth hormone a 4-year-old obese boy died from apparent worsening of obstructive sleep apnea and bronchopneumonia and a 7-year-old boy died because of pulmonary hypertension and a presumed cardiac event. Mortality is increased in Prader-Willi syndrome, but the rate has not been well quantified in this age group. These cases do not demonstrate causality, but in conjunction... 

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