Obsessive-compulsive disorder pathophysiology

Zohar J, Insel T OCD Psychobiological approaches to diagnosis, treatment and pathophysiology. Biol Psychiatry 22 667-687, 1987 Zohar J, Mueller EA, Insel TE, et al Serotonergic responsivity in obsessive-compulsive disorder comparison of patients and healthy controls. Arch Gen Psychiatry 44 946-951, 1987... 

Dopamine and obsessive-compulsive disorder. Up to 40% of OCD patients do not respond to SSRIs, Thus, at least some OCD patients fail to demonstrate convincing dys-regulation in serotonin function. Therefore, other neurotransmitters may be involved in the pathophysiology of OCD in some patients. 

Zohar J, Insel TR (1987) Obsessive-compulsive disorder psychobiological approaches to diagnosis, treatment, and pathophysiology. Biol Psychiatry 22 667-687... 

Pathophysiological basis of panic disorder and obsessive-compulsive disorder pharmacological treatment... 

Although DSM-IV includes twelve types of anxiety disorders, the list of disorders in this chapter is somewhat more brief. Patients suffering from post-traumatic stress disorder (PTSD) and a related disorder, acute stress disorder often do present with a host of anxiety symptoms however, anxiety is but one aspect of PTSD. This syndrome also often includes symptoms of depression, transient psychosis, and dissociation. Thus, we have chosen not to address it here, but in a separate chapter (see chapter 10). Additionally, although obsessive-compulsive disorder (OCD) is considered to be an anxiety disorder, its pathophysiology and treatment varies enough from the anxiety disorders to warrant a separate chapter (see chapter 8). 

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